The effects of creatine monohydrate supplementation on creatine transporter activity and creatine metabolism in resistance trained males

Background Oral creatine supplementation is known to provide numerous benefits, including increases in lean muscle mass, muscular strength, and enhanced performance in various athletic capacities. The creatine transporter is a transmembrane protein that mediates the entry of creatine from the circulation into the muscle cell. Little is understood about the importance of the creatine transporter in controlling the uptake and regulation of creatine within human skeletal muscle. The purpose of this study was to conduct a preliminary examination of the effects of a typical creatine monohydrate supplementation regimen on the activity of the creatine transporter at the transcriptional and translational levels in resistance-trained males.